Intranasal midazolam in piglets: pharmacodynamics (0.2 vs 0.4 mg/kg) and pharmacokinetics (0.4 mg/kg) with bioavailability determination
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منابع مشابه
Pharmacokinetics and pharmacodynamics of a new intranasal midazolam formulation in healthy volunteers.
We evaluated the pharmacokinetics and pharmacodynamics of single 5-mg doses of midazolam after administration of a novel intranasal (IN) formula, IM, and IV midazolam in an open-label, randomized, 3-way cross-over study in 12 healthy volunteers. IN doses were delivered as 0.1-mL unit-dose sprays of a novel formulation into both naris. Blood samples were taken serially from 0 to 12 h after each ...
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Pacéré as the demiurge of orature Not all unwritten literatures are oral literatures. They would more appropriately be referred to as “spoken literatures”, in the wider sense of literatures that use different means of communication (mouth, gestures, body movement, instruments). The dumb “speak” with signs. Pio Zirimu proposed the term “orature” to palliate the alleged contradiction in the phras...
متن کاملPharmacokinetics, pharmacodynamics, and safety of USL261, a midazolam formulation optimized for intranasal delivery, in a randomized study with healthy volunteers.
OBJECTIVE To compare the pharmacokinetics, pharmacodynamics, and tolerability of USL261, a midazolam formulation optimized for intranasal delivery, versus midazolam intravenous (IV) solution administered intranasally (MDZ-inj IN) or intravenously (MDZ-inj IV) in healthy adults. METHODS In this phase 1, five-way crossover, open-label study, 25 healthy adults (aged 18-42 years) were randomly as...
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One hundred eighty-eight seizure episodes in 46 children were randomly assigned to receive treatment with rectal diazepam and intranasal midazolam with doses of 0.3 mg/kg body weight and 0.2 mg/kg body weight, respectively. Efficacy of the drugs was assessed by drug administration time and seizure cessation time. Heart rate, blood pressure, respiratory rate, and oxygen saturation were measured ...
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Background and Aim: The final objective of root canal therapy is to create a hermetic seal along the length of the root canal system from the coronal opening to the apical termination and to accomplish the best adaptation of obturation material with canal walls. The purpose of this study was to compare the microleakage during lateral condensation of 0.04 and 0.02 tapered gutta-percha master con...
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ژورنال
عنوان ژورنال: Laboratory Animals
سال: 2000
ISSN: 0023-6772,1758-1117
DOI: 10.1258/002367700780578073